Normal Hair Growth and Common Hair Loss

normal hair growth cycle

smoothly, each terminal scalp hair normally grows continuously for about about three to five years. Then, the hair transitions in a resting state in which the visible part above the skin is shed. No hair grows from follicles for 90 days. After this time has passed, the new hair starts to grow through the skin and continue for another three to five years in the rate of about 1 / 2 inch per month.

It is believed that as many as 100 genes involved in regulating the creation, development and cycling of the hair. To date, very few of these genes have been identified.

common pattern hair loss

Hamilton-Norwood Hair Loss Scale

For those concerned about hair loss, many myths and half-truths abound, but useful information can be difficult to obtain. So, to review the pattern of hair loss is presented in this document.

In a healthy well-nourished people of both sexes, the most common form of hair loss is androgenetic alopecia (AGA), also known as pattern kose.Poremećaj loss affects about 40 million American men. Perhaps surprisingly, the same disorder affects about 20 million American women. The difference between men and women is that women suffer hair loss usually retains her feminine experience thinning hair and behind this leading edge. In men, the different "pattern" statement shows where the frontal edge of the leaves at the same time that the thinning zone extends from the rear of the crown. In pronounced cases, these zones meet and the person is said to be clinically bald.

Three triggers

Importantly, three things must happen in order for one to be affected by the AGA. First, it must inherit a genetic predisposition. This means that the problem comes from one or both sides of the family. Secondly, we need to reach a certain age. Nine years old children do not experience hair loss pattern. And third, it should be circulating hormones that accelerate the onset and progression of disease.

Typically, the earliest start of AGA occurs in late adolescence or someone in the early 20's. As a general rule, the earlier hair loss begins, the more pronounced is likely to become.

hormones, enzymes and other factors

DHT molecule crystallography
From the viewpoint of sensitivity, the principle is linked to hormonal trigger pattern hair loss is 5-alpha dihydrotestosterone, commonly known as DHT. Intriguing, which showed that people in genetically resistant to DHT, the pattern of hair loss does not occur. DHT is synthesized from testosterone and androgen hormone that is beneficial early in life and during puberty.

In adults, DHT is thought to cause significant damage, but very little good. Disorders such as various benign prostatic hyperplasia and pattern of hair loss are both run DHT.Sinteza DHT comes from two closely related forms of the enzyme 5-alpha reductase. Hair loss treatment options that effectively disrupt the interaction between 5-alpha reductase and androgen hormones such as testosterone have been shown to offer clinical benefit in the treatment of pattern hair loss.

Since hair growth is regulated by multiple genes and the attendant biochemical pathways, the underlying factors are extremely complex. Another challenge for the understanding of hair loss is the fact that people are just among mammals, suffering from androgenetic alopecia. Therefore, it is not efficient animal model exists that would otherwise tend to shed light on the key factors at work.

Hair Loss Variations In AGA

in both genders, the differential diagnosis is usually made ​​based on patient history and clinical prezentacije.Zajedničke differences in AGA were alopecia areata (AA), trichotillomania, and telogen effluvium. Less often, the cause of hair loss may be associated with disorders such as lupus erythematosis, scabies and other skin diseases manifesting process. Scalp biopsy and lab test may be useful in determining the final diagnosis, but in such cases, usually only need to follow the initial clinical assessment by a qualified physician.

pattern hair loss treatment options

This wryly observed that the choice for dealing with hair loss as "carpets, plugs, or drugs." This quip articulates three treatment options that are more kindly called non-surgical hair systems, surgical hair restoration, and farmakoterapija.Četvrti option has recently evolved, which will also be touched on here. This is a non-drug based treatment.

non-surgical restoration

Typically drier Piece

hair replacement systems are in regular use at least since ancient Egypt. These products also go to the concept of integration of the hair, wigs, weaves, hair pieces, toupees, and many other names. All have one thing in common --- not growing out of someone's head. Therefore, they must somehow be related to the bald skin or hair left edge above the ears and the back of the head.

hair replacement systems are in regular use at least since ancient Egypt. These products also go to the concept of integration of the hair, wigs, weaves, hair pieces, toupees, and many other names. All have one thing in common --- not growing out of someone's head. Therefore, they must somehow be related to the bald skin or hair left edge above the ears and the back of the head.

hair replacement systems are in regular use at least since ancient Egypt. These products also go to the concept of integration of the hair, wigs, weaves, hair pieces, toupees, and many other names. All have one thing in common --- not growing out of someone's head. Therefore, they must somehow be related to the bald skin or hair left edge above the ears and the back of the head.

hair replacement systems are in regular use at least since ancient Egypt. These products also go to the concept of integration of the hair, wigs, weaves, hair pieces, toupees, and many other names. All have one thing in common --- not growing out of someone's head. Therefore, they must somehow be related to the bald skin or hair left edge above the ears and the back of the head.

Since the nonliving, hair systems must be serviced and eventually own zamijeniti.Troškovi servicing and maintenance of the hair replacement is not unrealistic -. And these costs can be dramatically exceed the initial cost of acquisition

Surgical hair restoration

Surgical hair restoration, better known as hair transplantation, exploiting a phenomenon first described in 1950. This phenomenon, donor dependence relates to the claim that the hair bearing tissue, when it moved before the balding scalp of the same person, and still produce a viable, energetic hair to continue in the new place, because otherwise, it was not "moved". In appropriately selected patients, surgical hair restoration can be a positive solution for pattern hair loss

There is an important warning hair transplantaciju.Prva related supply and demand. At the present time, no one can transplant hair from one person to another without causing rumen and destructive foreign body response to the recipient. So, both operators and patients were relegated to what permanent hair bearing tissue in place. Therefore, it is very important to preserve the strategic position this precious resource in an appropriate manner.

Another major warning concerning a hair transplant to achieve clinically useful end rezultate.Kosa line that is spotty or too abrupt may seem worse than it was before it was restored. By the same token, the hair behind the edge of which is not restored in a manner that provides meaningful density (eg, 1 hair per mm / m²) is often not nearly full head of hair. Therefore, when choosing a transplant surgeon, artistic excellence is at least equal in importance to the basic surgical skills.

The third warning for hair transplantation refers to the problem known as chasing a receding hair line. Because hair loss is progressive and relentless, it is possible that donor hair re-integrate into apparently intact areas of hair can end up as an island of hair because the hair behind it and continue to erode. In this case, patients are forced to increase the hair behind the reconstruction zone in order to maintain a full appearance. This works fairly well until no hair stops thinning or one eventually run out of donor hair.

The third warning for hair transplantation refers to the problem known as chasing a receding hair line. Because hair loss is progressive and relentless, it is possible that donor hair re-integrate into apparently intact areas of hair can end up as an island of hair because the hair behind it and continue to erode. In this case, patients are forced to increase the hair behind the reconstruction zone in order to maintain a full appearance. This works fairly well until no hair stops thinning or one eventually run out of donor hair.

drug based hair loss treatment options

drug based hair loss treatment options

drug based hair loss treatment options

drug based hair loss treatment options

Benefits of Rogaine (TM) include the ability to arrest and possibly reverse, the pattern of hair loss. Based on Pfizer's own marketing materials, Rogaine (TM) is primarily shown to be effective in treating hair loss in the scalp and back skin, but not the front hair. Minoxidil is a potent drug with potential side effects including hypotension and skin irritation.

finasteride

finasteride, a selective type II 5-alpha reductase inhibitor, was originally developed in the 5 mg dose, under the trade name Proscar (TM) for the treatment of benign prostatic hyperplasia (BPH). Since BPH is associated with the same biochemical metabolic pathways that trigger pattern hair loss, it was postulated that finasteride may be clinically useful for both diseases. From this work, Propecia (TM) (1 mg finasteride) has been developed. In placebo-controlled studies in humans with mild to moderate hair loss, Propecia (TM) has been shown to produce clinically relevant benefit in the arrest, and in some cases, reverse the progression of the disease. Propecia (TM) is indicated for use in women. Reported side effects include decreased libido and decreased volume of ejaculate. Gynecomastia (male breast enlargement) is another potential side effect. Finasteride can also artificially lower levels of key proteins (PSA) used to screen for prostate cancer. Finasteride is considered a teratogen (can cause birth defects feminizing) and should not be handled by pregnant women or even those who may come into contact with pregnant women.

dutasteride

Like finasteride, dutasteride was originally developed to treat BPH. Unlike finasteride, however, dutasteride inhibits both isoforms of 5-alpha reductase, while finasteride inhibits only type II 5-alpha reductase. Interestingly, clinical studies conducted by GlaxoSmithKline, epics trial did not find dutasteride to be more effective than finasteride in treating BPH.

At the present time, dutasteride has been approved for the treatment of BPH. Clinical trials for dutasteride as a hair loss drug were undertaken, but was stopped by end of 2002. Potential side effects noted with the use of dutasteride as gynecomastia, changes in PSA, teratogenic effects, and others to closely parallel the negative side-effect profile described by makers of finasteride.

In December 2006, GlaxoSmithKline launched a new phase III study of six months in Korea to test the safety, tolerability and efficacy of once-daily dose of dutasteride (0.5mg) for the treatment of AGA in the top of the scalp (types IIIv, IV and V on Hamilton-Norwood scale). Given the impact that this study will be in the FDA approval or disapproval of avodart for the treatment of male pattern baldness in the United States has yet to be determined.

other drugs

On the occasion, but especially in patients of drugs, including spironalactone flutamide are used to mark off-label to treat various forms of hair loss. Every drug comes with a number of potential side effects, and none has been approved by the FDA for the treatment of pattern hair loss.

non-drug based hair loss treatment options

Recently, a botanical derived ingredients are under serious investigation as potentially useful tools against AGA. This effort was largely pioneered makers HairGenesis (TM). After creating HairGenesis (TM) and many other products came to market. Some built-drugs such as minoxidil. Second, using variations on the theme of non-drug based formulations. However, other than HairGenesis (TM), nor is it supported by a third party, IRB monitored, placebo-controlled, double-blind study - published in peer-reviewed medical literature. It does HairGenesis (TM) is unique in the category. For those who want to see how HairGenesis (TM) is deemed to be compared with other hair loss treatment options, review HairGenesis (TM) Comparison Page is encouraged.

Since most of this web site focuses on the benefits associated with HairGenesis (TM), a number of points for the benefit of HairGenesis (TM) treatment will not be repeated here. Two points are relevant for the present discussion, however, will be concisely articulated.

First, a complex of naturally derived active ingredients used in HairGenesis (TM) have been shown to act through the pathways and mechanisms that are unique from each other as separate and apart from those in which drug-based treatments work. Suffice it to say that this observation has presented a unique opportunity to develop HairGenesis in a "cocktail" treatment in which the formulation of synergy is likely to happen.

in plain English, this means that HairGenesis (TM) is designed to be greater than the sum of its parts.

Another key point is that research is being actively makers HairGenesis (TM) for the development of new, more advanced and stronger versions. Such improvements will be reported appropriately.